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Table of Contents
특징 #
- Immortality
- Produce "Go" signals
- Overide "Stop" signals
- Resist cell death
- Angiogenesis
- Metastasis
Clonal expansion: Cancer is a multi-gene, multi-step disease originating from single abnormal cell (clonal origin)
Carcinogenesis #
Process of tumor induction and development (Tumorigenesis 라고도 한다)
- Initiating agent
- Chemical carcinogenes
- Viruses
- Unknown factors
- Radiation, UV light
- Replication errors
- Promoting agent
- Specific promoters
- Inflammation
- Hormone
- Normal growth promoters etc.
- Growth inhibitors
- Hormones - therapeutic or physiological
- Normal growth inhibitors
- Age, surgery, radiation, etc.
특정 변이가 Cell signaling의 변화를 일으키고, 이것이 암으로 발전한다.
용어 #
Neoplasia (new growth), Neoplasm (=tumor)
Malignant neoplasm이 우리가 보통 얘기하는 Cancer.
Tumor development
- Hyperplasia: Increase in number of cells in response to stimulus (e.g. Hormones) reversible process
- Dysplasia: abnormal type of excessive cell proliferation
- Cancinoma in situ: uncontrolled growth of cell (do not invade)
Tumor grade
- grade 1: well differentiation, slow-growling, low malignancy
- grade 2: mild differentiation, middle malignancy
- grade 3: poor differentiation, fast-growing, nigh malignancy
Tumor stage
- T: primary tumor
- N: regional lymph node involvement
- M: metastases
Nomenclature
| Pattern | Differentiation | Benign | Malignant |
|---|---|---|---|
| Epitherial | Glandular / ductal epithelium | Adenoma (선종) | Adenocarcinoma (선암) |
| Epitherial | Liver | Hepatic adenoma | Hepatoma |
| Mesenchymal | Muscle | Leiomyoma | Leiomyosarcoma |
| Mesenchymal | Adipocyte | Lipoma | Liposarcoma |
| Mesenchymal | Bone | Osteoma | Osteosarcoma |
| Mesenchymal | Cartilage | Chondroma | Chondrosarcoma |
| Mesenchymal | Endothelial | Hemangioma | Hemangiosarcoma |
| Melanocytic | Melanocytic nervus | Melanoma | |
| Glial | Astrocytoma, Ependymoma | ||
| Hematopoetic | Leukemia (백혈병), Lymphoma (림프종) |
관련링크 #
교육자료 #
동영상 #
- 생물정보학 기법을 통합 암의 맞춤형 치료 CSBI KAIST
- 바이오정보학과 표적 항암치료 CSBI KAIST
슬라이드 #
- 암의 이해 단국의대 최상규 : 알기쉬운 일반 정리
기술자료 #
논문 #
- Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015 - A Systematic Analysis for the Global Burden of Disease Study JAMA Oncology : 세계 암 통계
- Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2014 Cancer Research Treatment : Korea 년 암 통계
- A Landscape of Pharmacogenomic Interactions in Cancer Cell
- Variation in cancer risk among tissues can be explained by the number of stem cell divisions Science : 암 원인의 2/3은 줄기세포 분열중 생긴 변이
블로그 포스팅 #
기사 #
- 美 암 발병 원인 분석해 보니… : 흡연, 간접 흡연, 초과 체중, 알코올 섭취, 붉은 살코기 및 가공육 소비, 과일 야채 낮은 소비, 운동 부족, 자외선
- 운 나쁜 변이는 암에 얼마나 기여하나 논쟁 재연 : 발암 변이의 2/3은 세포가 DNA를 복제할 때 발생하는 오류 때문
- 4600조원 거대 시장을 노린 음모?... 무시무시한 '암'의 역사 : 의료분야의 문제점을 지적하는 것까진 좋은데 일부 잘못된 정보를 전달함 - 우리는 이미 수많은 암세포들과 함께 살고 있다. 그네들이 용케 1g 이상이 되면 그때서야 우리는 그들을 알아볼 수 있다. 어떤 문제들로 그들이 암이 되었는지는 이미 거의 알고 있다. 이를 치료하기 어려울 뿐.
- 왜 우리는 암과의 전쟁이서 이기지 못하고 있는가 NewsPeppermint : 암은 수백 가지 혹은 수천 가지 다른 방식으로 일어나는 복잡한 과정. 그리고 암 자체가 계속 변화한다는 것
- 암의 가장 큰 원인은 불운(不運) BRIC 동향
- 암 유발 대사물질 발굴하는 컴퓨터 세포모델 개발...한미 공동연구팀
Incoming Links #
[Medical Scholarly Articles] About (MedicalScholarlyArticle 0) #
- Complex landscapes of somatic rearrangement in human breast cancer genomes
- Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality
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- APOBEC
- Allele-specific copy number
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- 생물정보관련 학술지 피인용지수(IF) 현황
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- Molecular and genetic properties of tumors associated with local immune cytolytic activity
- Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality
- The cancer genome
- The landscape of somatic copy-number alteration across human cancers
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