Cancer epigenetics is the study of epigenetic modifications to the genome of cancer cells that do not involve a change in the nucleotide sequence (http://en.wikipedia.org/wiki/Cancer_epigenetics)

Cancer Epigenetics. Epigenetic alteration in tumor progression

개요 #

Categories

1. Silencing of Tumor suppressor genes by local hypermethylation of DNA
2. Global changes in DNA methylation
3. Changes of Histone modifications.

Genes

1. DNMT23A - DNA methylation
2. MLL1, MLL2 - Histone methylation
3. CREBBP/EP300 - Histone acetylation

Noncoding RNAs and Cancer

1. OncomiRs: miR-200, miR-155
2. Tumor suppressive miRs: miR-15, miR-16
3. Tumor suppressive properties of mIR processing factors: DICER

관련자료 #

논문 #

• Epigenetics of breast cancer: Biology and clinical implication in the era of precision medicine Seminars in Cancer Biology 2018-01-12: Breast cancer 후성유전 리뷰
• A chemical probe toolbox for dissecting the cancer epigenome Nature Reviews Cancer 2017-03-10
• Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis Clinical Epigenetics 2015-04-04

기사 #

• 종양 병인학과 진행에서 후성유전적 조절인자, 변화인자, 그리고 매개인자 2018-02-01: Nature Reviews Genetics 논문 한국어 리뷰

Incoming Links #

Related Medical Scholarly Articles (MedicalScholarlyArticle 0) #

• The cancer genome

Related Books (Book 1) #

• Drug Discovery in Cancer Epigenetics

[Books] About (Book 2) #

• Drug Discovery in Cancer Epigenetics

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