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Tumor suppressor gene #
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A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer. (

It's absense can lead to Cancer (see also Oncogene)

If a pair of tumor suppressor genes are either lost from a cell or inactivated by mutation, their functional absense might allow cancer to develop.

Tumor suppressor gene은 Oncogene과 다르게 두개의 대립유전자 가운데, 둘 다 고장나야 의미가 있다. 이를 "Two-hit hypothesis" 혹은 Knudson hypothesis이라고 한다.

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