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Lung cancer #
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Lung Cancer (폐암), also known as Lung carcinoma is a malignant Lung tumor characterized by uncontrolled cell growth in tissues of the Lung. If left untreated, this growth can spread beyond the lung by the process of Metastasis into nearby tissue or other parts of the body. (https://en.wikipedia.org/wiki/Lung_cancer)

Category and incidence #

Multistep lung cancer model (classic) #

  1. Normal epithelium
    • <- 9p and 3p losses
  2. Hyperplasia
    • <- 17p loss
  3. Mild dysplasia
    • <- Telomerase activation
  4. Moderate dysplasia
    • <- p53 mutation and VEGF overexpression
  5. Server dysplasia
    • <- p16 inactivation, BCL2 overexpression
  6. In situ carcinoma
    • <- Cyclin D1 and E overexpression
  7. Invasive carcinoma

Adenocarcinoma Molecular pathology - target #

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