APOBEC ("apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like") is a family of evolutionarily conserved proteins. (https://en.wikipedia.org/wiki/APOBEC)
RNA editing 단백질들은 단백질 다양성을 늘리는 역할을 한다. C-to-U RNA editing을 수행하며, N 말단에 cytidine deamination 도메인이, C 말단에 유사촉매 도메인이 있다. 또한 Virus의 mRNA를 편집함으로써 바이러스 저항성을 키우는 역할 수행한다.
이 유전자의 활성에 이상이 있으면, Mutational signature 2, 13 패턴의 치환 변이들이 높게 발견된다.
관련 논문
- An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers Nature Genetics : APOBEC 변이가 Cancer에 다양하게 발견된다고.
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