APOBEC ("apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like") is a family of evolutionarily conserved proteins. (https://en.wikipedia.org/wiki/APOBEC)
RNA editing 단백질들은 단백질 다양성을 늘리는 역할을 한다. C-to-U RNA editing을 수행하며, N 말단에 cytidine deamination 도메인이, C 말단에 유사촉매 도메인이 있다. 또한 Virus의 mRNA를 편집함으로써 바이러스 저항성을 키우는 역할 수행한다.
이 유전자의 활성에 이상이 있으면, Mutational signature 2, 13 패턴의 치환 변이들이 높게 발견된다.
관련 논문
- An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers Nature Genetics : APOBEC 변이가 Cancer에 다양하게 발견된다고.
Incoming Links #
Related Medical Scholarly Articles (MedicalScholarlyArticle 0) #
- Landscape of somatic mutations in 560 breast cancer whole-genome sequences
- Mechanisms underlying mutational signatures in human cancers
Related Articles (Article 1) #
Suggested Pages #
- 0.200 Homologous recombination
- 0.113 MutaGene
- 0.043 Mutational processes molding the genomes of 21 breast cancers
- 0.032 A mutational signature in gastric cancer suggests therapeutic strategies
- 0.025
- 0.025 Melanoma
- 0.025 Base exision repair
- 0.025 Chondroma
- 0.025 November 1
- 0.024 April
- More suggestions...