Somatic Evolution is the accumulation of mutations in the cells of a body during a lifetime, and the effects of those mutations on the fitness of those cells. (https://en.wikipedia.org/wiki/Somatic_evolution_in_cancer)
암조직에는 실제로 서로 다른 세포들이 함께 있으며(Tumour heterogeneity) 각자 진화하고 있다.
- Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity Nature Biotechnology
- Clonal evolution in cancer Nature
- Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing PNAS Peter Campbell and Michael Stratton