A microRNA (abbreviated miRNA) is a small Non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of Gene expression (http://en.wikipedia.org/wiki/MicroRNA)

siRNA는 100% 매치해야 gene silencing 되지만, miRNA는 70%만 매치되어도 됨

TargetScan 사이트에서 예측 기능 제공

miRNA and Cancer #

miR-15a, miR-16-1의 deletion이 CLL환자의 65%에서 발견됨. 다른 유전자가 없는 것으로 보아, 이 miRNA가 암과 관련있음. -- BCL2를 repress하는 것으로 생각됨

관련 링크 #

기사 #

• 암세포 공격! 새로운 마이크로RNA

논문 #

• Knowledge about the presence or absence of miRNA isoforms (isomiRs) can successfully discriminate amongst 32 TCGA cancer types Nucleic Acids Research 2017-02-16: Machine learning 방법으로 TCGA miRNA 데이터 분석하여 32개 암종 구분

Incoming Links #

Related Medical Scholarly Articles (MedicalScholarlyArticle 0) #

• Breast cancer epigenetics: from DNA methylation to microRNAs
• Landscape of somatic mutations in 560 breast cancer whole-genome sequences
• Methods of integrating data to uncover genotype–phenotype interactions

Related Articles (Article 1) #

• Epigenetics
• Gene expression
• Machine learning for Genomics
• Non-coding RNA
• siRNA
• 암 맞춤의학과 생물정보학

Related Books (Book 2) #

• Epigenetics in Human Disease

[Datasets] About (Dataset 3) #

• miRBase

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