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Histone-lysine N-methyltransferase NSD3 is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The WHSC1L1 gene is amplified in several cancers, including Lung cancer and head and neck cancer, and may play a role in Carcinogenesis. (https://en.wikipedia.org/wiki/WHSC1L1)

NSD family의 Histone methyltransferase - H3K36, H3K4, H3K27를 메틸화하여 근처 유전자를 활성화시키거나, 저해시킨다.

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