Comparative genomic hybridization (CGH) is a molecular cytogenetic method for analysing copy number variations (CNVs) relative to ploidy level in the DNA of a test sample compared to a reference sample, without the need for culturing cells. (http://en.wikipedia.org/wiki/Comparative_genomic_hybridization)
정상인 DNA와 환자 DNA를 섞어서 칩을 찍으면 환자 DNA가 없거나 더 많은 부분을 알 수 있다. CNVs를 알 수 있다. (= Array CGH)
This technique was originally developed for the evaluation of the differences between the chromosomal complements of Solid tumor and normal tissue, and has an improved resolution of 5-10 megabases compared to the more traditional cytogenetic analysis techniques of giemsa banding and fluorescence in situ hybridization (FISH) which are limited by the resolution of the microscope utilized.
Two applications
- Conventional CGH
- Array CGH
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