Comparative genomic hybridization (CGH) is a molecular cytogenetic method for analysing copy number variations (CNVs) relative to ploidy level in the DNA of a test sample compared to a reference sample, without the need for culturing cells. (http://en.wikipedia.org/wiki/Comparative_genomic_hybridization)

정상인 DNA와 환자 DNA를 섞어서 칩을 찍으면 환자 DNA가 없거나 더 많은 부분을 알 수 있다. CNVs를 알 수 있다. (= Array CGH)

This technique was originally developed for the evaluation of the differences between the chromosomal complements of Solid tumor and normal tissue, and has an improved resolution of 5-10 megabases compared to the more traditional cytogenetic analysis techniques of giemsa banding and fluorescence in situ hybridization (FISH) which are limited by the resolution of the microscope utilized.

Two applications

1. Conventional CGH
2. Array CGH

Incoming Links #

[Medical Scholarly Articles] About (MedicalScholarlyArticle 0) #

• Comparative analysis of algorithms for identifying amplifications and deletions in array CGH data

Related Books (Book 1) #

• Epigenetics in Human Disease

Related Articles (Article 2) #

• Copy-number variation

Related Education Events (EducationEvent 3) #

• Genomics and Precision Medicine

Related Medical Scholarly Articles (MedicalScholarlyArticle 4) #

• CODEX: a normalization and copy number variation detection method for whole exome sequencing

Related Codes (Code 5) #

• ngCGH

Suggested Pages #

• 0.095 Amplicon
• 0.091 Cattle
• 0.064 COSMIC
• 0.058 CBS
• 0.047 AscatNgs
• 0.042 Gene expression
• 0.039 Liver cancer
• 0.035 Affymetrix Power Tools
• 0.029 Comprehensive molecular portraits of human breast tumours
• 0.025 CNVkit
• More suggestions...