Comparative genomic hybridization (CGH) is a molecular cytogenetic method for analysing copy number variations (CNVs) relative to ploidy level in the DNA of a test sample compared to a reference sample, without the need for culturing cells. (http://en.wikipedia.org/wiki/Comparative_genomic_hybridization)

정상인 DNA와 환자 DNA를 섞어서 칩을 찍으면 환자 DNA가 없거나 더 많은 부분을 알 수 있다. CNVs를 알 수 있다. (= Array CGH)

This technique was originally developed for the evaluation of the differences between the chromosomal complements of Solid tumor and normal tissue, and has an improved resolution of 5-10 megabases compared to the more traditional cytogenetic analysis techniques of giemsa banding and fluorescence in situ hybridization (FISH) which are limited by the resolution of the microscope utilized.

Two applications

1. Conventional CGH
2. Array CGH

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• Comparative analysis of algorithms for identifying amplifications and deletions in array CGH data

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• Copy-number variation

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• ngCGH

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