히스톤 아세틸화. Histone modification의 한가지.

Histone 아세틸화로 chromatin이 느슨해지고, 유전자들이 발현된다.

Genes affected by acetylation in Carcinogenesis.

1. directly affect the promoter
2. affect coactivators or transcription factor
3. affect the expression and stability of proteins

Histone acetyltransferase (HAT) #

• GNAT
• MYST
• p300/CBP

Histone deacetylase (HDAC) #

• I: HDAC1, HDAC2, HDAC3, HDAC8
• IIA: HDAC4, HDAC5, HDAC7, HDAC9
• IIB: HDAC6, HDAC10
• III: SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7
• IV: HDAC11

Incoming Links #

Related Medical Scholarly Articles (MedicalScholarlyArticle 0) #

• Covalent modifications of histones during development and disease pathogenesis

Related Articles (Article 1) #

• Cancer epigenetics
• Histone modification
• SIRT2
• X-inactivation

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