Table of Contents
Main questions #
Materials and methods #
Main finding of the paper #
An average of 17% of the genome was amplified and 16% deleted in a typical cancer sample compared to average of 0.35% and less than 0.1% in normal samples
In a typical cancer sample, 25% of the genome is affected by arm-level SCNAs and 10% by focal SCNAs, with 2% overlap.
Pooled analysis of focal SCNAs #
Specific gene families and pathways are over-represented among focal SCNAs #
Second 키워드는 NF-κB 임.
Amplifications of MCL1 and BCL2L1 are associated with MCL1 and BCL2L1 dependence #
The vast majority of significant focal SCNAs in each cancer type are prevalent across other types #
17개 cancer type 모두 대략 유사함.
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