Table of Contents
Main questions #
Materials and methods #
Main finding of the paper #
An average of 17% of the genome was amplified and 16% deleted in a typical cancer sample compared to average of 0.35% and less than 0.1% in normal samples
In a typical cancer sample, 25% of the genome is affected by arm-level SCNAs and 10% by focal SCNAs, with 2% overlap.
Pooled analysis of focal SCNAs #
Specific gene families and pathways are over-represented among focal SCNAs #
Second 키워드는 NF-κB 임.
Amplifications of MCL1 and BCL2L1 are associated with MCL1 and BCL2L1 dependence #
The vast majority of significant focal SCNAs in each cancer type are prevalent across other types #
17개 cancer type 모두 대략 유사함.
Tumorscape 사이트를 통해 축적된 데이터를 확인할 수 있음.
Remaining questions to be addressed #
The biological insight that could be gained from this study #
Incoming Links #
Related Articles (Article 0) #
Suggested Pages #
- 0.175 Comparative genomic hybridization
- 0.132 Cattle
- 0.060 Battenberg
- 0.048 Amplicon
- 0.038 Identification of cancer-driver genes in focal genomic alterations from whole genome sequencing data
- 0.036 CBS
- 0.035 Comparative analysis of algorithms for identifying amplifications and deletions in array CGH data
- 0.031 CoNIFER
- 0.027 Affymetrix Power Tools
- 0.026 COSMIC
- More suggestions...