Cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal Stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. (http://en.wikipedia.org/wiki/Cancer_stem_cell CSC)

Within a tumor that have the capacity to initiate and sustain the tumor (less than 1%)

• Self-renewal (persistent proliferation potential)
• Exclusive in vivo tumorigenicity
• Metastasis and invasion
• Tumor recurrence, resistant to treatment

마커

• CD44+, CD24-
• ALDH1

Pathway

• Notch signaling pathway
• Hedgehog signaling pathway
• Wnt signaling pathway

관련 정보

• 암 줄기세포 연구에 대한 동향 및 개념 2017-08-10
• 암줄기세포 모델의 진화 2016-08-01: BRIC 동향
• 국내 연구진, 암줄기세포 에너지 대사 규명 BRIC 동향 2015-07-17: Colorectal cancer CSC 미토콘드리아 에너지 대사과정 규명
• 암 줄기세포를 둘러싼 도박 BRIC 동향 2015-01-19

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