Myc (c-Myc) is a regulator gene that codes for a Transcription factor. The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in Cell cycle progression, Apoptosis and Cellular transformation. (http://en.wikipedia.org/wiki/Myc)

Hallmarks of Cancer

• MYC activates the expression of many genes that are involved in cell growth.
  • target D cyclin
  • upregulate expression of rRNA --> Ribosome, Protein synthesis
  • upregulate metabolic reprogramming and Warbug effect
  • master transcriptional regulator of cell growth
• MYC upregulates expression of Telomerase
• MYC is one of a handful of Transcription factors that can act together to reprogram somatic cells into pluripotent Stem cells.
• Through MYC upregulation,
  • RAS-MAPK signaling pathway (many cancers)
  • Notch signaling pathway (several hematologic cancers)
  • Wnt signaling pathway (colon carcinoma)
  • Hedgehog signaling pathway (medulloblastoma)

It's deregulation (Oncogene effect) by

1. Alteration of MYC itself
2. Translocation
3. Amplified in some Breast cancer, colon, lung,...

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