Myc (c-Myc) is a regulator gene that codes for a Transcription factor. The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in Cell cycle progression, Apoptosis and Cellular transformation. (http://en.wikipedia.org/wiki/Myc)
Hallmarks of Cancer
- MYC activates the expression of many genes that are involved in cell growth.
- target D cyclin
- upregulate expression of rRNA --> Ribosome, Protein synthesis
- upregulate metabolic reprogramming and Warbug effect
- master transcriptional regulator of cell growth
- MYC upregulates expression of Telomerase
- MYC is one of a handful of Transcription factors that can act together to reprogram somatic cells into pluripotent Stem cells.
- Through MYC upregulation,
- RAS-MAPK signaling pathway (many cancers)
- Notch signaling pathway (several hematologic cancers)
- Wnt signaling pathway (colon carcinoma)
- Hedgehog signaling pathway (medulloblastoma)
It's deregulation (Oncogene effect) by
- Alteration of MYC itself
- Translocation
- Amplified in some Breast cancer, colon, lung,...
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