Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. (https://en.wikipedia.org/wiki/HIF1A)

The dysregulation and overexpression of HIF1A by either hypoxia or genetic alternations have been heavily implicated in cancer biology, as well as a number of other pathophysiologies, specifically in areas of Vascularization and Angiogenesis, Energy metabolism, Cell survival, and Tumor invasion.

관련정보

• 암 발생, 전이의 새로운 조절 기전 규명 2016-02-16: 저산소 환경에서 발현이 유도되며, 암발생 및 전이를 촉진하는데 중요한 역할 수행 - 히프원 단백질에 메틸화가 일어나면 단백질이 분해되어 Cancer 발생 및 Metastasis가 억제되며, 이와 반대로 히프원 단백질에 메틸화가 억제되면 단백질이 안정화되어 암 발생 및 전이가 촉진되는 새로운 조절 기전을 발견

Suggested Pages #

• 0.025 2015
• 0.025 2017
• 0.025 Melanocytic nervus
• 0.025 June 2
• 0.025 2013
• 0.025 CDKN2A
• 0.025 Exome sequencing
• 0.025 September 24
• 0.025 Cancer Research Treatment
• 0.025 Liposarcoma
• More suggestions...