DNA Methylation (DNA 메틸화) is a biochemical process where a methyl group is added to the cytosine or adenine DNA nucleotides. Epigenetics의 대표사례. (http://en.wikipedia.org/wiki/DNA_methylation)
Genome 전반에 걸쳐있는 이것을 Methylome라고도 한다.
다음의 실험으로 확인할 수 있다.
- Mass spectrometry
- Whole genome bisulfite sequencing
- Methylated DNA immunoprecipitation (MeDIP)
- Pyrosequencing
- DNA methylation array
Table of Contents
DNA methyltransferase #
DNA에 메틸기를 전달함
Leukemia에 DNMT inhibitor이 효과 있음
- Nucleoside inhibitor
- Non-nucleoside inhibitor
관련논문 #
- Statistical and integrative system-level analysis of DNA methylation data Nature Review Genetics
- DiffVar: a new method for detecting differential variability with application to methylation in cancer and aging Genome Biology : Cancer와 Ageing에서 DNA methylation 차이를 탐지하는 방법 Illumina HumanMethylation450 BeadChip 사용.
관련정보 #
- 유전자 조절 기능 ‘제6의 DNA 염기’? 사이언스온 : 메틸-시토신(mC)가 제5의 염기, 메틸-아데닌(mA)이 제 6의 염기라고 주목중
- DNA 메틸화의 반전: 메커니즘, 유전체학, 생물학적 기능 BRIC 동향
Incoming Links #
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