CNV. Genome의 특정 영역이 누락되거나, 여러번 반복되는 것. Genetic variation의 한가지. (http://en.wikipedia.org/wiki/Copy_number_variation)
Somatic cell에서의 이것을 특별히 SCNA (Somatic copy-number alteration) 혹은 CNA라고 한다. SCNA의 발생은 Cancer 주요 기작 중 하나이다. CNA를 allele별로 분석하는 것을 Allele-specific copy number이라고 한다.
다음의 실험으로 알 수 있다.
- Comparative genomic hybridization (Array CGH)
- SNP array
- WGS
- Exome sequencing (See also CNV calling from NGS data)
Table of Contents
관련 자료 #
Copy number variation and the secret of life - Gene duplication and Evolution - with Aoife McLysaght
관련 프로그램 #
From SNP array
관련 논문 #
Cancer SCNA 일반
- Punctuated copy number evolution and clonal stasis in triple-negative breast cancer Nature Genetics : TNBC에서 copy number Evolution 확인
- The landscape of somatic copy-number alteration across human cancers Nature
SCNA 탐지 방법
- Identification of cancer-driver genes in focal genomic alterations from whole genome sequencing data Scientific Reports
관련링크 #
- 人CoDOM:CNV: Hyungyong Kim이 작성한 CNV 개요
관련기관 #
Incoming Links #
[Medical Scholarly Articles] About (MedicalScholarlyArticle 0) #
[Codes] About (Code 1) #
Related Datasets (Dataset 2) #
Related Software Applications (SoftwareApplication 3) #
Related People (Person 4) #
Related Products (Product 5) #
Related Articles (Article 6) #
- Allele-specific copy number
- Amplicon
- CBS
- CNV calling from NGS data
- CODEX: a normalization and copy number variation detection method for whole exome sequencing
- Cattle
- Comparative genomic hybridization
- Gene expression
- Genetic variation
- Nanopore sequencing
- Ploidy
- SNP array
- eQTL
- 암 맞춤의학과 생물정보학
Related Education Events (EducationEvent 7) #
[Datasets] About (Dataset 8) #
Related Medical Conditions (MedicalCondition 9) #
Related Medical Scholarly Articles (MedicalScholarlyArticle 10) #
- Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA
- CODEX: a normalization and copy number variation detection method for whole exome sequencing
- Comparison of custom capture for targeted next-generation DNA sequencing
- Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers
- Comprehensive molecular portraits of human breast tumours
- Computational methods for detecting copy number variations in cancer genome using next generation sequencing
- Gene-based comparative analysis of tools for estimating copy number alterations using whole-exome sequencing data
- Genetic alterations of histone lysine methyltransferases and their significance in breast cancer
- Genetic alterations of triple negative breast cancer by targeted next-generation sequencing and correlation with tumor morphology
- Identification of cancer-driver genes in focal genomic alterations from whole genome sequencing data
- Methods of integrating data to uncover genotype–phenotype interactions
- Pathway and network analysis of cancer genomes
- SAAS-CNV: A Joint Segmentation Approach on Aggregated and Allele Specific Signals for the Identification of Somatic Copy Number Alterations with Next-Generation Sequencing Data
- The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
- The landscape of somatic copy-number alteration across human cancers
Related Codes (Code 11) #
Suggested Pages #
- 0.327 Tumorscape
- 0.048 세미나 발표: 유전변이의 비밀
- 0.041 SnpEff
- 0.031 GENT
- 0.028 CODEX
- 0.027 Genomics and Precision Medicine
- 0.026 Cancer genomics
- 0.025 Structural variation
- 0.024 Genomic imprinting
- 0.024 saasCNV
- More suggestions...