Autophagy (or autophagocytosis, 오토파지, 자가소화작용) is the natural, regulated, destructive mechanism of the cell that disassembles unnecessary or dysfunctional components. (https://en.wikipedia.org/wiki/Autophagy)
오토파지 메커니즘
- 거대자가포식(Macroautophagy)
- 미세자가포식(Microautophagy)
- 샤프론(chaperone)매개 자가포식 (Chaperone-mediated autophagy)
Cancer 형성 초기에는 종양억제인자로서 작용하고 종양이 상당부분 진행된 경우에는 종양촉진인자로 작용하는 것으로 보인다.
관련논문
- AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy Nature : AMPK-SKP2-CARM1 Cell signaling 확인
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