PARP inhibitor
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- (rev. 3)
- Hyungyong Kim
Structured data
PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP)
Homologous recombination에 관여하는 PARP를 저해함으로 DNA repair를 못해서 Cancer cell이 사망하게 된다. 주로 BRCA1/BRCA2 결함 환자에게 적용한다.
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