Cadherin-1 also known as CAM 120/80 or epithelial cadherin (E-cadherin) or uvomorulin is a protein that in humans is encoded by the CDH1 gene. CDH1 has also been designated as CD324 (cluster of differentiation 324). It is a Tumor suppressor gene. (CDH1 in Wikipedia)

Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or Metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells, and the cytoplasmic domain is required for internalization.

Breast cancer에서 종종 DNA methylation (hyper-methylation)되어 있다고 보고됨.

Incoming Links #

Related Medical Scholarly Articles (MedicalScholarlyArticle 0) #

• Comprehensive molecular portraits of human breast tumours
• Is the future of personalized therapy in triple-negative breast cancer based on molecular subtype

Related Articles (Article 1) #

• SNAI1
• 암 맞춤의학과 생물정보학

Related Books (Book 2) #

• Drug Discovery in Cancer Epigenetics
• Robbins and Cotran Pathologic Basis of Disease

Suggested Pages #

• 0.353 APC
• 0.074 Tumor suppressor SET9 guides the epigenetic plasticity of breast cancer cells and serves as an early-stage biomarker for predicting metastasis
• 0.025 2017
• 0.025 April 2
• 0.025 Oncogene
• 0.024 Tamoxifen
• 0.023 Two-hit hypothesis
• 0.023 2014
• 0.023 October 9
• 0.023 Leukemia
• More suggestions...