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Philadelphia chromosome #
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The Philadelphia chromosome or Philadelphia translocation is a specific abnormality of chromosome 22, which is unusually short, as an acquired abnormality that is most commonly associated with Chronic myelogenous leukemia (CML). (

9번 염색체와 22번 염색체사이의 전좌(Chromosomal translocation)로 9번의 ABL1과 22번의 BCR이 융합된 Fusion gene BCR-ABL1이 생기고, Oncogene 활성을 나타냄.

Imatinib이 치료에 사용된다. TKI 역할을 한다.

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