Polycomb-group (PcG) proteins are a family of proteins first discovered in fruit flies that can remodel Chromatin such that epigenetic silencing of genes takes place. (http://en.wikipedia.org/wiki/Polycomb-group_proteins)

PcG complexes

1. RPC1 (maintain)
   • BMI1
   • MEL-18 (PCGF2)
   • CBX
2. RPC2 (initiation)
   • EZH2
   • SUZ12

Functions

1. PcG proteins silence some Tumor suppressor genes.
2. PcG proteins regulate stem cells.
3. PcG proteins and the links to signaling pathways

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