Homologous recombination (상동재조합, HR) is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical molecules of DNA. (https://en.wikipedia.org/wiki/Homologous_recombination)

HR을 통해 DNA의 double strand break repair를 할 수 있는데, BRCA1, BRCA2가 기능을 못하면 이것이 어려워지고, Mutational signature 3 형태의 돌연변이가 많아짐.

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• BRCA1
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• PARP inhibitor

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