BRCA2 is a human Tumor suppressor gene (specifically, a caretaker gene), found in all humans; its protein, also called by the synonym Breast cancer type 2 susceptibility protein, is responsible for DNA repair. (http://en.wikipedia.org/wiki/BRCA2)

Michael Stratton이 1994년 발견함. 이를 기념하여, Addenbrooke's Hospital 부근 cycle and foot path를 만듬

Incoming Links #

Related Drug Classes (DrugClass 0) #

• PARP inhibitor

Related Books (Book 1) #

• Robbins and Cotran Pathologic Basis of Disease

Related People (Person 2) #

• Michael Stratton

Related Articles (Article 3) #

• DNA repair
• Homologous recombination
• Homologous recombination deficiency
• Mutational signature
• Triple-negative breast cancer
• 암 맞춤의학과 생물정보학

Related Education Events (EducationEvent 4) #

• Genomics and Precision Medicine

Related Medical Conditions (MedicalCondition 5) #

• Breast cancer
• Pancreatic cancer

Related Medical Scholarly Articles (MedicalScholarlyArticle 6) #

• Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches
• Mechanisms underlying mutational signatures in human cancers

Suggested Pages #

• 0.086 Nucleotide excision repair
• 0.071 CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer
• 0.066 CDK12
• 0.052 Non-homologous end joining
• 0.048 PARP
• 0.047 Mutational processes molding the genomes of 21 breast cancers
• 0.046 HMEC
• 0.044 BT-474
• 0.038 Breast cancer epigenetics: from DNA methylation to microRNAs
• 0.035 Therapeutic opportunities within the DNA damage response
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