METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) is a Canada-UK project that aims to classify breast tumours into further subcategories, based on molecular signatures that will help determine the optimal course of treatment.

1,981 샘플에 대한 다음 정보를 텍스트, 바이너리 형식으로 각각 다운받을 수 있다.

1. Gene expression
2. CNV
3. Clinical features
4. Clinical disease specific survival
5. Clinical overall survival

Gene expression과 CNV는 controlled access data로 별도로 신청해서 받아야 한다. 별도의 IRB 승인이 필요하다. 원본 데이터는 EBI에서도 받을 수 있다. 마찬가지로 IRB 필요.

데이터 구조 #

Clinical data #

• id: MB-0000, MB-0002,...
• age_at_diagnosis: 76.65, 43.19,...
• size: 22, 10,...
• lymph_nodes_positive: 10, 0, 45,...
• grade: 3, 2,...
• histological_type: IDC, IDC+ILC, Other invasive,...
• ER_IHC_status: pos, neg,...
• ER.Expr: +
• PR.Expr: -
• HER2_IHC_status: NA, 0,...
• HER2_SNP6_state: NEUT, GAIN, LOSS,...
• Her2.Expr: -
• Treatment: HT/RT, CT/HT/RT,...
• NOT_IN_OSLOVAL_menopausal_status_inferred: post, pre,...
• NOT_IN_OSLOVAL_group: 4,
• NOT_IN_OSLOVAL_stage: 2,
• NOT_IN_OSLOVAL_lymph_nodes_removed: 16, 39,...
• NOT_IN_OSLOVAL_NPI: 6.02, 4.02,...
• NOT_IN_OSLOVAL_cellularity: high, moderate,...
• NOT_IN_OSLOVAL_P53_mutation_status: MUT-MISSENSE, WT,...
• NOT_IN_OSLOVAL_P53_mutation_type: MB-AD-0002+ex5,...
• NOT_IN_OSLOVAL_P53_mutation_details: 6+chr17:7519122+12521A>AC+178H>H/P+MISSENSE+FR+FR,
• NOT_IN_OSLOVAL_Pam50Subtype: Normal, LumA, LumB, HER2, Basal,...
• NOT_IN_OSLOVAL_IntClustMemb: 4, 7,...
• NOT_IN_OSLOVAL_Site: 1, 4,...
• NOT_IN_OSLOVAL_Genefu: ER+/HER2- High Prolif, ER+/HER2- Low Prolif,...

Survival data #

• Overall survival: 1981 patients (ID/time/status)
• Clinical survival: ? (time/status)

Gene expression #

Complete normalized expression data (CSV, 1.5GB, 47567 probes)

1. Illumina HT-12 v3 997 primary tumours, 144 normals
2. Spatial artifact correction, summarization, normalization of Log2 intensities

CNV #

Complete normalized CNV data (CSV, 668MB, 18539 probes)

1. Genome-Wide Human SNP Array 6.0 997 primary tumours, 473 normals
2. Prove-level modeling, normalization, summarization of Log2 intensities

관련 정보 #

기사

• Increasing the resolution on breast cancer – the METABRIC study 2012-04-18

논문

• The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups Nature 2012-06-21

Incoming Links #

Related Articles (Article 0) #

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Related Medical Scholarly Articles (MedicalScholarlyArticle 1) #

• BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells
• Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer
• The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

Related Education Events (EducationEvent 2) #

• 2015 통계유전학워크숍

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