SCNA가 driver인지 구분하는 방법은 후보 타겟 유전자를 포함하느냐 임. 다수 환자의 SNP array 결과로부터 이를 분석하는 방법이 발전해 왔으나, NGS는 probe 없는 고해상도 데이터이며, 부정확하게 매핑된 리드들로 인해 적용이 어렵다.

WIFA-Seq이라는 WGS 데이터에서 focal genomic alteration을 찾는 방법을 만들었고 테스트함.

Summary #

Introduction #

Materials and methods #

Overview of the WIFA-Seq precedure #

Data sets #

Data pre-processing #

Wavelet transform for an individual patient #

Integrating CNA regions for multiple patients #

False discovery control options #

Parameters in WIFA-Seq #

Results #

The number of segments in 37 patients with GBM #

Focal copy number alterations in 37 patients with GBM #

Focal alterations in 47 patients with OV #

Focal alterations in 28 patients with LUAD #

Discussion #

Incoming Links #

Related Articles (Article 0) #

• Copy-number variation

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