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Redirected from Gene fusion
A fusion gene is a hybrid gene formed from two previously separate genes. It can occur as a result of: Chromosomal translocation, interstitial deletion, or Chromosomal inversion. (http://en.wikipedia.org/wiki/Fusion_gene)
일부 Cancer에서 Non Receptor tyrosine kinase 활성의 Oncogene 효과로 보고되고 있다.
대표적인 것이 Chronic myelogenous leukemia (CML) 혹은 일부 Acute lymphoblastic leukemia (ALL)에서 발견되는 BCR-ABL1 tyrosine kinase 활성이다. (Philadelphia chromosome)
관련논문
- TumorFusions: an integrative resource for cancer-associated transcript fusions Nucleic Acids Research
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