A tyrosine kinase inhibitor (TKI) or tyrosine phosphorylation inhibitor (Tyrphostin) is a pharmaceutical drug that inhibits RTK. (https://en.wikipedia.org/wiki/Tyrosine-kinase_inhibitor)
RTK를 인산화시키는 과정을 저해한다.
주요 약물
- Nilotinib for BCR/ABL1 Fusion gene
- Imatinib for CML
- Gefitinib, Erlotinib at EGF receptor
- Sunitinib at FGF, PDGF, VEGF
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