The JAK-STAT signaling pathway transmits information from chemical signals outside the cell, through the cell membrane, and into gene promoters on the DNA in the cell nucleus, which causes DNA transcription and activity in the cell. (http://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway)

The JAK-STAT system consists of three main components:

1. A receptor
2. Janus kinase (JAK)
3. Signal Transducer and Activator of Transcription (STAT)

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