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Non-receptor tyrosine kinase #
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Non-receptor tyrosine kinases (nRTKs) are cytoplasmic enzymes that are responsible for catalysing the transfer of a phosphate group from a nucleoside triphosphate donor, such as ATP, to a tyrosine residues in proteins. (

Unlike the Receptor tyrosine kinases (RTKs), these are cytoplasmic enzymes.

다음과 같은 Oncogene 활성이 보고된 바 있다.

  1. BCR-ABL Gene fusion
  2. JAK2 point mutation activates JAK-STAT signaling pathway

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