The Epidermal growth factor receptor (EGFR; ERBB1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. (https://en.wikipedia.org/wiki/Epidermal_growth_factor_receptor)

ERBB family members

1. ERBB1 (EGFR, HER1)
2. ERBB2 (HER2)
3. ERBB3 (HER3)
4. ERBB4 (HER4)

변이별 처방

1. G719X: Gefitinib, Erlotinib 반응성 좋음
2. E19 del: Gefitinib, Erlotinib 반응성 좋음
3. T790M: Gefitinib, Erlotinib 내성
4. S768I: Gefitinib, Erlotinib 반응성 있음 (low level)
5. E20 Ins.3dup: Gefitinib, Erlotinib 반응없음
6. E20 Ins.3: Gefitinib, Erlotinib 반응없음
7. L858R or 861Q: Gefitinib, Erlotinib 반응성 좋음

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