The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells. It makes Cell growth. (http://en.wikipedia.org/wiki/Cell_cycle)
G1 (presynthetic growth) -> S (DNA synthesis) -> G2 (premitotic growth) -> M (mitotic)
- G0 (quiescent/senescent)
- Interphase
- G1
- S
- G2
- Mitotic phase (Mitosis)
Each stage requires completion of the previous step, as well as activation of necessary factors; nonfidelity of DNA replication, or cofactor deficiency result in arrest at the various transition points.
The cell cyle is regulated by activators and inhibitors.
Cell cycle progression is driven by proteins called Cyclins - named for the cyclic nature of their production and degradation - and cyclin-associated enzymes called Cyclin-dependent kinases (CDKs).
CDKs acquire the ability to phosphorylate protein substrates (i.e., kinase activity) by forming compexes with the relevant cyclins.
Transiently increased synthesis of a particular cyclin leads to increased kinase activity of the appropriate CDK binding partner; as the CDK completes its round of phosphorylation, the associated cyclin is degraded and the CDK activity abates.
Thus, as cyclin levels rise and fall, the activity of associated CDKs likewise wax and wane.
More than 15 cyclins have been identified; cyclins D, E, A, and B appear sequentially during the cell cycle and bind to one or more CDKs.
관련정보
Table of Contents
Incoming Links #
Related Articles (Article 0) #
Related Medical Scholarly Articles (MedicalScholarlyArticle 1) #
- Biomarkers in triple negative breast cancer: A review
- Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers
- Covalent modifications of histones during development and disease pathogenesis
- Is the future of personalized therapy in triple-negative breast cancer based on molecular subtype
- Patterns of somatic mutation in human cancer genomes
Related Books (Book 2) #
Related Drugs (Drug 3) #
Suggested Pages #
- 0.097 Haploview
- 0.080 Polycomb regulates mesoderm cell fate-specification in embryonic stem cells through activation and repression mechanisms
- 0.078 Induced pluripotent stem cell
- 0.075 RAS
- 0.073 PDCD5
- 0.065 MEL-18 loss mediates estrogen receptor–α downregulation and hormone independence
- 0.047 Receptor tyrosine kinase
- 0.045 Polycomb-group proteins
- 0.040 Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response
- 0.036 Landscape of somatic mutations in 560 breast cancer whole-genome sequences
- More suggestions...