In biochemistry and genetics, base excision repair (BER) is a cellular mechanism that repairs damaged DNA throughout the Cell cycle. It is responsible primarily for removing small, non-helix-distorting base lesions from the genome. (https://en.wikipedia.org/wiki/Base_excision_repair)
One of the single strand breaks DNA repair mechanism.
PARP1, PARP2가 SSB를 찾는 중요한 센서임. XRCC1과 결합하고 nuclease APE1과도 결합한다. 최종적으로 endonuclease FEN1이 이를 쪼갠다.
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