Polycomb regulates mesoderm cell fate-specification in embryonic stem cells through activation and repression mechanisms
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- (rev. 1)
- Hyungyong Kim
Structured data
- About
- MEL-18
- Date Published
- Publisher
- Cell Stem Cell
- URL
- http://www.ncbi.nlm.nih.gov/pubmed/26340528
Data is available in GEO: GSE67868
Table of Contents
Summary #
Introduction #
Results #
Mel18 Binds to cPRC1 Target Genes, Regulates Transcription, and Stabilizes the cPRC1 Complex Only in ESCs #
Mel18 Is Necessary for Proper Cardiac Differentiation of Embryoid Bodies #
Mel18 Is Essential for ESCs to Differentiate into Early MES Cells #
PRC1 Complex Composition and Genome-wide Binding in MES Cells #
Mel18 Directly Regulates Expression of MES-Specific Genes #
Mel18 Directly Controls Negative Regulators of the BMP Pathway in MES Cells #
Mel18 Depletion Blocks CM and Cartilage Differentiation #
Discussion #
Suggested Pages #
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- 0.025 Protein-protein interaction
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- 0.025 Cancer
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