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Polycomb regulates mesoderm cell fate-specification in embryonic stem cells through activation and repression mechanisms #
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Structured data

About
MEL-18
Date Published
Publisher
Cell Stem Cell
URL

Data is available in GEO: GSE67868

Summary #

Introduction #

Results #

Mel18 Binds to cPRC1 Target Genes, Regulates Transcription, and Stabilizes the cPRC1 Complex Only in ESCs #

Mel18 Is Necessary for Proper Cardiac Differentiation of Embryoid Bodies #

Mel18 Is Essential for ESCs to Differentiate into Early MES Cells #

PRC1 Complex Composition and Genome-wide Binding in MES Cells #

Mel18 Directly Regulates Expression of MES-Specific Genes #

Mel18 Directly Controls Negative Regulators of the BMP Pathway in MES Cells #

Mel18 Depletion Blocks CM and Cartilage Differentiation #

Discussion #

Suggested Pages #

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