KRAS also known as V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, is a GTPase that in humans is encoded by the KRAS gene.

Ras GTPase의 한가지

변이별 처방

1. G12X, G13X
   • 일반암: Gefitinib이나 Erlotinib과 같은 tyrosine kinase inhibitor 약물에 반응성 감소
   • 결장암: Erbitux나 Vectibix 반응성 감소

관련 기사

• 난공불락의 표적, KRAS를 겨냥하는 신무기 둘 개발 2019-10-31
• 난공불락 'KRAS 타깃' 항암제 개발위한 3가지 접근법 2016-12-21

관련 논문

• An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer Nature Communications 2017-02-21: FOSL1이 KRAS 변이와 관련있다고

Incoming Links #

Related Medical Scholarly Articles (MedicalScholarlyArticle 0) #

• Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality
• The cancer genome
• The landscape of somatic copy-number alteration across human cancers

Related Articles (Article 1) #

• Lung cancer
• Personalized medicine
• RAS
• Ras GTPase
• 암 맞춤의학과 생물정보학

Related Education Events (EducationEvent 2) #

• Genomics and Precision Medicine

Related Drugs (Drug 3) #

• Cobimetinib

Suggested Pages #

• 0.261 NF1
• 0.118 ACE
• 0.090 Cell-free tumor DNA
• 0.082 Receptor tyrosine kinase
• 0.059 Pathology
• 0.030 Renin–angiotensin system
• 0.025 Copy-number variation
• 0.025 Machine learning for Genomics
• 0.023 Cancer
• 0.022 GTP
• More suggestions...