KRAS also known as V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, is a GTPase that in humans is encoded by the KRAS gene.

Ras GTPase의 한가지

변이별 처방

1. G12X, G13X
   • 일반암: Gefitinib이나 Erlotinib과 같은 tyrosine kinase inhibitor 약물에 반응성 감소
   • 결장암: Erbitux나 Vectibix 반응성 감소

관련 기사

• 난공불락의 표적, KRAS를 겨냥하는 신무기 둘 개발 2019-10-31
• 난공불락 'KRAS 타깃' 항암제 개발위한 3가지 접근법 2016-12-21

관련 논문

• An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer Nature Communications 2017-02-21: FOSL1이 KRAS 변이와 관련있다고

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