The Notch signaling pathway is a highly conserved Cell signaling system present in most multicellular organisms. Mammals possess four different Notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. (https://en.wikipedia.org/wiki/Notch_signaling_pathway)

The notch receptor is a single-pass Cell surface receptor. It is a hetero-oligomer composed of a large extracellular portion, which associates in a calcium-dependent, non-covalent interaction with a smaller piece of the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small intracellular region. Notch signaling promotes proliferative signaling during neurogenesis, and its activity is inhibited by NUMB to promote neural differentiation. It plays a major role in the regulation of Embryonic development.

Incoming Links #

Related Articles (Article 0) #

• Cancer stem cell
• MYC

Related Medical Scholarly Articles (MedicalScholarlyArticle 1) #

• Is the future of personalized therapy in triple-negative breast cancer based on molecular subtype

Suggested Pages #

• 0.623 ADAM10
• 0.047 암 맞춤의학과 생물정보학
• 0.035 Induced pluripotent stem cell
• 0.022 2017
• 0.022 G protein-coupled receptor
• 0.021 Biological network
• 0.017 Receptor tyrosine kinase
• 0.015 Embryology
• 0.015 Nature Review Genetics
• 0.013 Genetic alterations of triple negative breast cancer by targeted next-generation sequencing and correlation with tumor morphology
• More suggestions...