Makes a protein called B-Raf. The gene is also referred to as proto-Oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B, while the protein is more formally known as serine/threonine-protein kinase B-Raf.
It sits at the top of a cascade of other serine/threonine kinases of the MAPK family. Activating mutations in BRAF stimulate each of these downstream kinases and ultimately activate transcription factors.
변이별 처방
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