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BRAF in Wikipedia

Makes a protein called B-Raf. The gene is also referred to as proto-Oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B, while the protein is more formally known as serine/threonine-protein kinase B-Raf.

It sits at the top of a cascade of other serine/threonine kinases of the MAPK family. Activating mutations in BRAF stimulate each of these downstream kinases and ultimately activate transcription factors.

변이별 처방

  1. V600E
    • 대장암: ErbituxVectibix와 같은 약물 반응성의 감소
    • 갑상선암
      1. 갑상선 호르몬 생합성에 필요한 유전자 발현이 감소되어 있어 갑상선 치료에 사용되는 radio-active iodine과의 친화력이 낮으며 내과적 치료에 사용되는 radioactive iodine 치료에 반응하지 않을 것으로 예측
      2. 악성 및 양성 종양인지 판별이 어려울 경우, BRAF 돌연변이가 발견되면 악성 진단 가능성이 높음
    • 피부암: Vemurafenib 약물 반응성 증가

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