Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene. (https://en.wikipedia.org/wiki/Anaplastic_lymphoma_kinase)
Brain development와 Nervous system의 특별한 Neuron 효과에 관여함. Receptor tyrosine kinase의 하나임. LTK와 높은 서열 유사성을 갖는다.
NSCLC에서 EML4-ALK Fusion gene이 잘 알려져 있다.
다음과 같은 ALK inhibitor들이 있다.
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