The epithelial-mesenchymal transition (EMT, 상피간엽이행) is a process by which epithelial cells lose their cell polarity and cell-cell adhesion, and gain migratory and invasive properties to become mesenchymal stem cells. (from Wikipedia)

These are multipotent stromal cells that can differentiate into a variety of cell types. EMT is essential for numerous developmental processes including Mesoderm formation and Neural tube formation. EMT has also been shown to occur in wound healing, in organ Fibrosis and in the initiation of Metastasis for Cancer progression.

특징

• Cell adhesion을 잃고
• 모양이 길쭉해짐
• Cancer stem cell의 특징을 가짐

마커

• Epithelial: E-cadherin
• Mesenchymal: SNAIL1, SNAIL2,...

관련 전사인자

• ZEB1, ZEB2
• SNAIL1, SNAIL2
• TWIST1

Patyway

• TGF beta signaling pathway

Role of Epithelial–mesenchymal transition (EMT) during cancer progression

• Assigning stem cell characteristics to didifferentiated tumor cells
• Redifine resident genetically altered stem cells to be Cancer stem cells
• The dissemination of thmor cells from the Solid tumor and subsequent migration
• Ready to move towards Metastasis
• Further promote resistance to tumor therapy, leading to recurrence and poor prognosis

관련정보

• 암의 발생 및 진행 과정에서 EMT를 규정하는 조절 네트워크 BRIC 동향 2015-04-20

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