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DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression #
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Summary #

Results #

DOT1L promotes EMT-induced breast tumour Metastasis #

DOT1L induces breast tumorigenesis by enhancing CSC activity #

DOT1L expands CSCs via increasing EMT-TFs #

DOT1L epigenetically derepresses EMT-TFs with c-Myc and p300 #

c-Myc is prerequisite for DOT1L-induced EMT-TF regulation #

Discussion #

Methods #

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