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GTPases are a large family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate (GTP). The GTP binding and hydrolysis takes place in the highly conserved G domain common to all GTPases.

GTPases play an important role in:

  • Signal transduction at the intracellular domain of transmembrane receptors, including recognition of taste, smell and light.
  • Protein biosynthesis (aka translation) at the ribosome.
  • Control and differentiation during cell division.
  • Translocation of proteins through membranes.
  • Transport of vesicles within the cell. (GTPases control assembly of vesicle coats).

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