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DNA mismatch repair #
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DNA mismatch repair (MMR) is a DNA repair system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage. (https://en.wikipedia.org/wiki/DNA_mismatch_repair)

전체 과정

  1. MutSɑ complex (detection of small mismatches, formed by Msh2/Msh6)와 MutSβ complex (detection of large mismatches and insertion loops, formed by Msh2/ Msh3)가 lesion을 탐지한다.
  2. PCNA/RFP complex와 결합
  3. exonuclease Exo1 결합한뒤 잘라냄
  4. DNA polymerase delta가 상보 DNA 합성
  5. DNA ligase I이 이어줌

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