Poly ADP ribose polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and Apoptosis. (https://en.wikipedia.org/wiki/Poly_ADP_ribose_polymerase)

The main role is to detect and signal single-strand DNA breaks (SSB) to the enzymatic machinery involved in the SSB repair.

DNA repair 관련 유전자의 고장시, PARP inhibitor로 이 유전자를 저해하면 Synthetic lethality 효과가 있다.

Members of PARP family

• PARP1, PARP2, PARP4, TNKS, TNKS2
• PARP3 ~ 16

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