Summary #

Microsatellite instability is detected in about 15% of all Colon cancers

1. 3% of Lynch syndromes
2. 12% sporadic acquired hypermethylation of promoter of the MLH1

MSI 없는 암에 비해 좀 더 나은 예후를 가짐

Introduction #

Models of CRC Pathogenesis #

MSI as a Unique Mechanism in Tumor Development #

DNA MMR System #

MSI is Caused by Deficiencies in MMR #

MMR Genes, HNPCC, Lynch Syndrome #

MLH1, PMS2, PMS1, and MSH6 #

Lynch syndrom #

MMR Gene Mutations in Lynch Syndrome #

MSI in Sporadic CRC #

Sporadic MSI and CpG island Methylator Pheontype #

Germline Epimutations #

Pathophysiology of Colorectal Carcinogenesis with MSI #

MSI and Inflammatory Bowel disease #

Models of MSI #

Stoichiometry of MMR Proteins #

Methylation of MLH1 #

Measuring MMR Dificiency #

MSI-High and MSI-Low #

Diagnosis of MSI #

MSI as a Predictor of Response to Chemotherapy #

Suggested Pages #

• 0.025 MSH1
• 0.025 MSH2
• 0.025 DNA mismatch repair
• 0.025 MSI
• 0.025 Bowel cancer
• 0.025 2019
• 0.025 Microsatellite
• 0.025 Rectal cancer
• 0.025 Oncotarget
• 0.025 HNPCC
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