Summary #

Introduction #

Results #

Large-scale survey of signature 3 across human neoplasia #

Patterns of indels and structural rearrangements #

Association between signature 3 and gastric cancer histology #

Presence of signature 3 in gastric cell lines #

Discussion #

Methods #

Curation of freely available somatic mutations of cancer samples #

Filtering of somatic mutations and generating mutational catalogues #

Estimating the contributions of mutational signatures in each sample #

Factors that influence extraction of mutational signatures #

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