Summary #

Introduction #

Results #

Sequencing of Breast Cancers #

The Catalogue of Somatic Mutations from 21 Breast Cancer Genome #

Extracting Mutation Signatures from Catalogues of Somatic Mutation #

Application of Mathematical Approaches to Extract Mutation Signatures #

Using Non-negative matrix factorization

Mutational Processes Generating Double-Nucleotide Substitutions #

Regional Hypermutation, Kataegis, Is Common in Breast Cancer #

The Relationship between Substitution Mutations and Transcription #

Microhomology-Mediated Deletions in BRCA1 and BRCA2 Mutant Cancers #

Discussion #

Suggested Pages #

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