Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme Telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. (http://en.wikipedia.org/wiki/Telomerase_reverse_transcriptase)

Deregulation of telomerase expression in somatic cells may be involved in Oncogenesis. GWAS suggest TERT is a susceptibility gene for development of many cancers, including Lung cancer.

관련 논문

• GWAS of epigenetic ageing rates in blood reveals a critical role for TERT bioRxiv 2017-06-30: "DNA methylation age"는 Ageing을 추정할 수 있는 바이오마커임. 9,907명 GWAS로 관련된 유전좌위를 찾음. TERT와 관련됨.

Incoming Links #

Related Medical Conditions (MedicalCondition 0) #

• Liver cancer

Related Articles (Article 1) #

• Telomere

Related Education Events (EducationEvent 2) #

• 2015 통계유전학워크숍

Suggested Pages #

• 0.357 Ageing
• 0.297 Hepatitis B
• 0.144 Mutational signature
• 0.009 Hyperlipidemia
• 0.008 Mutational processes molding the genomes of 21 breast cancers
• 0.008 MutaGene
• 0.008 Gut microbiota
• 0.008 Presbyopia
• 0.007 October 24
• 0.007 Lipoma
• More suggestions...