Programmed cell death protein 1, also known as PD1 and CD279 (cluster of differentiation 279), is a cell surface receptor that plays an important role in down-regulating the Immune system and promoting self tolerance by suppressing T cell inflammatory activity. PD-1 is an Immune checkpoint and guards against autoimmunity through a dual mechanism of promoting Apoptosis in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in Regulatory T cells. (https://en.wikipedia.org/wiki/Programmed_cell_death_protein_1)

면역을 억제하는 역할. 암세포 표면의 PD-L1, PD-L2와 결합하면 T cell은 암세포를 공격하지 못한다. 면역항암제는 PD-1 수용체와 결합하여 암세포의 회피 기능을 억제한다.

관련정보

• PD-1 저해제, 때로는 암을 되레 악화시켜 2017-04-03: 항 PD-1 치료를 받은 환자 가운데, 9%는 종양 성장 가속 - MDM2, MDM4 유전자를 여분으로 갖고 있거나, EGFR 변이가 있는 경우 종양이 신속하게 성장

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