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A Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM10 or CDw156 or CD156c is a protein that in humans is encoded by the ADAM10 gene. (

One of the ADAM family. Members of the ADAM family are cell surface proteins with a unique structure possessing both potential Cell adhesion and Protease domains.

The transmembrane metalloprotease ADAM10 sheds a range of cell surface proteins, including ligands and receptors of the Notch, EPH, and ERBB families, thereby activating signaling pathways critical for tumor initiation and maintenance. --> promising therapeutic target.

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