Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. (https://en.wikipedia.org/wiki/Sirtuin_1)

One of Histone deacetylases.

Ageing 관련 연구가 많이 되고 있음. Diabetes mellitus와도 관련있음.

관련정보 #

논문 #

• SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential Diabetes Metab J 2013-10-17: Calorie restriction은 Ageing을 늦추는 효과가 있는데, 이는 SIRT1이 활성화됨으로 기능한다. 당, 지방 대사를 조절한다. pancreatic β-cells에서는 Insulin의 분비를 조절하고, oxidative stress와 inflammation으로 부터 세포를 보호한다.
• Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes Cell Metab 2013-03-05

Incoming Links #

Related Medical Conditions (MedicalCondition 0) #

• Ageing

Related Articles (Article 1) #

• Calorie restriction
• Histone acetylation

Related Books (Book 2) #

• Why We Get Sick

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