HMG-CoA reductase (or 3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGCR) is the rate-controlling enzyme (EC 1.1.1.88& EC 1.1.1.34) of the Mevalonate pathway, that produces Cholesterol and other Isoprenoids. (http://en.wikipedia.org/wiki/HMG-CoA_reductase)

It converts HMG-CoA to Mevalonate.

이 효소는 Cholesterol에 의해 저해되며, 이는 간세포의 LDL receptor의 증가로 이어져, 콜레스테롤 농도를 낮추게 된다. Statin 같은 약물이 저해제로 작용한다.

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